L
Levin Life Sciences Consulting
Needham, MA

Lead Discovery — Protein Science — CRO & Program Strategy

Senior discovery
leadership
without the hire.

Early-stage companies get a founder and senior discovery leader embedded at the level of a Head of Lead Discovery or Protein Science. Guiding target validation, assay strategy, CRO oversight, and program prioritization, at a fraction of the cost and none of the hiring risk.

Engagements begin with a 30-minute scoping call
01
Lead Discovery
HTS campaign design, hit-to-lead strategy, chemotype prioritization, and IND-track program leadership — grounded in integrated screening campaigns spanning DEL, ASMS, high-content imaging, and traditional HTS.
02
Protein Science
Target expression and purification, biophysical characterization (SPR, MST, ITC, DSF), structural biology, target engagement, and assay development.
03
CRO & Program Strategy
Vendor scoping, assay transfer, milestone design, and scientific oversight — so your experiments return data you can actually build on.

Drug discovery is a decision problem disguised as a science problem.

The data exists. The decision is what’s missing.
Which target do we commit to?
Wrong call $1M—$5M burned. Program death.
Time lost 18—36 months before the data forces the decision you needed at the start.
Is this CRO the right partner for this assay?
Wrong call $500K—$2M in misallocated spend.
Time lost 6—12 months to discover the data can’t be built on. Then another search.
Is this assay result interpretable enough to act on?
Wrong call $100K—$500K in follow-on work that compounds a false signal.
Time lost 3—6 months of campaign time before the assay is re-validated from scratch.
Should this program be killed now?
Wrong call $250K—$1M and opportunity cost compounds across the entire portfolio.
Time lost 6—18 months of spend on a low-probability asset.

The relevant comparison is not hourly rate against hourly rate. It is the full cost of the alternative — including recruiter fees, ramp time, equity dilution, and the cost of a hire who doesn’t work out — against the cost of the decision infrastructure you actually need.

City Director FTE, fully loaded / yr FTE cost / mo LLSC / mo
Boston / Cambridge $432,000 $36,000
San Francisco $469,000 $39,083 $9,000
New York City $462,000 $38,500

Director-level midpoint salary, 20% bonus, 84% employer healthcare (single), 4% 401K match, FICA 7.65%.
Recruiter fees ($60K—$80K) and equity excluded. No hiring risk. No search cycle.

Case Study
Assay rescue under deadline pressure
Target engagement · Volastra Therapeutics · Fractional consulting engagement
Challenge

An in-cell direct target engagement assay had stalled during optimization. The path forward was unclear, the method was technically complex, and the project timeline was at risk.

Approach

Ben audited the assay architecture and drew on direct hands-on experience with the method to identify the highest-impact optimization surfaces. He assessed the options, weighed the tradeoffs, and delivered a prioritized strategy in a single engagement.

Outcome

The assay was resolved using initial suggestions alone — no additional iteration required. Project timeline preserved. The same consultant was brought back for a second independent engagement.

What clients say

“If you want an engaged, curious professional, I highly recommend reaching out to Ben Levin.”

Steve Wittenberger  —  Sr. VP, Process & Development, 1200 Pharma

“Ben is experienced in cell biology, protein science, and lead discovery — and always a pleasure to work with. His communication skills are great and he is always responsive.”

Ryan Wenzel  —  Director of North American Operations, CovalX
Engagements begin with a 30-minute scoping call